REARRANGEMENT STUDIES WITH C14: XVI. REARRANGEMENTS INDUCED BY γ -IRRADIATION OF 2-PHENYLETHYL-1-C14 BROMIDE OR 2-p-METHOXYPHENYLETHYL-1-C14 BROMIDE

Conversion of DL-lactate-2-C14 or -3-C14 or pyruvate-2-C14 to blood glucose in humans: effects of diabetes, insulin, tolbutamide, and glucose load.

Metabolism of pyruvic acid-2-C14 and hydroxypyruvic acid-2-C14 in algae.

The metabolism of pyruvic acid in the light and dark by Scenedesmus has been examined with two aims: to study the relationship of its metabolism to that of the intermediates of C1402 fixation and to compare its metabolic fate with that of hydroxypyruvate. The metabolism of hydroxypyruvic acid was compared with that of C1402 fixation in order to ascertain whether it might be a photosynthetic int...

The incorporation of formate-C14, glycine-2-C14, adenine-4, 6-C14, and phosphate-P32 into nucleic acids.

nine labeled either with C'4 or N'5. Considerable controversy has developed as to which one of these tracer compounds gives an accurate measurement of the “relativeturnover-rate― of the nucleic acids. In order to determine the “absolute turnover rate― of the nucleic acids, it is necessary to know the specific activity of the immediate precursor of the nucleic acids. Since even the ident...

Synthesis of D-Glucose-1-C14 and D-Mannose-1-C14

Heretofore, radiochemical yields of sugars position-labeled with carbon-14 have been only 5 to 10 percent. This paper reports an improved cyanohydrin synthesis, and the preparation of D-glucose-1-C and D-mannose-1-C from D-arabinose in yields of about 50 percent. Low yields in prior syntheses appear to have been due to several inefficient steps, and to the fact that extension of the carbon chai...

Studies on fluorinated pyrimidines. III. The metabolism of 5-fluorouracil-2-C14 and 5-fluoroorotic-2-C14 acid in vivo.

As one of the initial steps towards the determi nation of the metabolism and mechanism of action of fluorinated pyrimidines, 5-fluorouracil and 5fluoroorotic acid were labeled with radiocarbon in the 2-carbon atom. We have previously reported briefly that fluorouracil is incorporated, as such, into the combined nucleic acids of mouse liver, spleen, and Ehrlich ascites cells (9). The present rep...